Strebhardt, Klaus: search on Z-Library

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1

Paul Ehrlich's magic bullet concept: 100 years of progress

Strebhardt, Klaus, Ullrich, Axel

Journal:

Nature Reviews Cancer

Year:

2008

Language:

english

File:

PDF, 861 KB

english, 2008

2

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

Strebhardt, Klaus

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 912 KB

english, 2010

3

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

Wolfgang Reindl, Klaus Strebhardt, Thorsten Berg

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 196 KB

english, 2008

4

Non-mitotic functions of polo-like kinases in cancer cells

Raab, Christopher A., Raab, Monika, Becker, Sven, Strebhardt, Klaus

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2021

File:

PDF, 9.76 MB

2021

5

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

Matthess, Yves, Raab, Monika, Knecht, Rainald, Becker, Sven, Strebhardt, Klaus

Journal:

Molecular Oncology

Year:

2014

Language:

english

File:

PDF, 2.31 MB

english, 2014

6

Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1

Matthess, Yves, Kappel, Sven, Spänkuch, Birgit, Zimmer, Brigitte, Kaufmann, Manfred, Strebhardt, Klaus

Journal:

Year:

2005

Language:

english

File:

PDF, 309 KB

english, 2005

7

Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy

Sibylle Loibl, Gunter von Minckwitz, Sonja Weber, Hans-Peter Sinn, Valérie B. Schini-Kerth, Irina Lobysheva, Françoise Nepveu, Georg Wolf, Klaus Strebhardt, Manfred Kaufmann

Journal:

Year:

2002

Language:

english

File:

PDF, 787 KB

english, 2002

8

Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery

Strebhardt, Klaus, Becker, Sven, Matthess, Yves

Journal:

Expert Opinion on Drug Discovery

Year:

2015

Language:

english

File:

PDF, 797 KB

english, 2015

9

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells

Raab, Monika, Pachl, Fiona, Krämer, Andrea, Kurunci-Csacsko, Elisabeth, Dötsch, Christina, Knecht, Rainald, Becker, Sven, Kuster, Bernhard, Strebhardt, Klaus

Journal:

Year:

2014

Language:

english

File:

PDF, 982 KB

english, 2014

10

Polo-Like Kinase 1 as Predictive Marker and Therapeutic Target for Radiotherapy in Rectal Cancer

Franz Rödel, Sarah Keppner, Gianni Capalbo, Robina Bashary, Manfred Kaufmann, Claus Rödel, Klaus Strebhardt, Birgit Spänkuch

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

11

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21 WAF1/CIP1

Kreis, Nina-Naomi, Sommer, Katharina, Sanhaji, Mourad, Krämer, Andrea, Matthess, Yves, Kaufmann, Manfred, Strebhardt, Klaus, Yuan, Juping

Journal:

Year:

2009

Language:

english

File:

PDF, 1.42 MB

english, 2009

12

Polo-like kinases and oncogenesis

Eckerdt, Frank, Yuan, Juping, Strebhardt, Klaus

Journal:

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

13

Morphological Alteration of X-ray Induced Partially Transformed Human Cells by Transfection with a Small c-myc DNA Sequence

Yoshio Kano, Tsutomu Nohno, Rei Takahashi, Fukumi Hiragami, Kenji Kawamura, Klaus Strebhardt, Masayoshi Namba, Taketoshi Sugiyama, John B. Little

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

14

Plk1: unexpected roles in DNA replication

Mandal, Ranadip, Strebhardt, Klaus

Journal:

Year:

2013

Language:

english

File:

PDF, 307 KB

english, 2013

15

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

Juping Yuan, Mourad Sanhaji, Andrea Krämer, Wolfgang Reindl, Matthias Hofmann, Nina-Naomi Kreis, Brigitte Zimmer, Thorsten Berg, Klaus Strebhardt

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

16

Biological impact of freezing Plk1 in its inactive conformation in cancer cells

Keppner, Sarah, Proschak, Ewgenij, Kaufmann, Manfred, Strebhardt, Klaus, Schneider, Gisbert, Spänkuch, Birgit

Journal:

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

17

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

Spänkuch-Schmitt, Birgit, Wolf, Georg, Solbach, Christine, Loibl, Sibylle, Knecht, Rainald, Stegmüller, Manfred, von Minckwitz, Gunter, Kaufmann, Manfred, Strebhardt, Klaus

Journal:

Year:

2002

Language:

english

File:

PDF, 418 KB

english, 2002

18

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

Wolf, Georg, Elez, Robert, Doermer, Andreas, Holtrich, Uwe, Ackermann, Hanns, Stutte, Hans Jochen, Altmannsberger, Hans-Michael, Rübsamen-Waigmann, Helga, Strebhardt, Klaus

Journal:

Year:

1997

Language:

english

File:

PDF, 644 KB

english, 1997

19

The role of early expression of inducible nitric oxide synthase in human breast cancer

Sibylle Loibl, Angela Buck, Cornelia Strank, Gunter von Minckwitz, Marc Roller, Hans-Peter Sinn, Valerie Schini-Kerth, Christine Solbach, Klaus Strebhardt, Manfred Kaufmann

Journal:

European Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 390 KB

english, 2005

20

Polo-like kinase: a novel marker of proliferation: Correlation with estrogen-receptor expression in human breast cancer

Georg Wolf, Ralf Hildenbrand, Christian Schwar, Rainer Grobholz, Manfred Kaufmann, Hans-Jochen Stutte, Klaus Strebhardt, Uwe Bleyl

Journal:

Pathology - Research and Practice

Year:

2000

Language:

english

File:

PDF, 1018 KB

english, 2000

21

Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases

Bräuminger, Andreas, Holtrich, Uwe, Strebhardt, Klaus, Rübsamen-Waigmann, Helga

Journal:

Year:

1992

Language:

english

File:

PDF, 971 KB

english, 1992

22

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

Helmke, Christina, Raab, Monika, Rödel, Franz, Matthess, Yves, Oellerich, Thomas, Mandal, Ranadip, Sanhaji, Mourad, Urlaub, Henning, Rödel, Claus, Becker, Sven, Strebhardt, Klaus

Journal:

Year:

2016

Language:

english

File:

PDF, 19.31 MB

english, 2016

23

The role of PLK1 in cancer exhibiting chromosomal instability

Strebhardt, Klaus, Raab, Monika, Sanhaji, Mourad

Journal:

Molecular & Cellular Oncology

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018

24

Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

Lucas Kneisel, Klaus Strebhardt, August Bernd, Manfred Wolter, Angelika Binder, Roland Kaufmann

Journal:

Journal of Cutaneous Pathology

Year:

2002

Language:

english

File:

PDF, 101 KB

english, 2002

25

Molecular classification of breast cancer patients by gene expression profiling

André Ahr, Uwe Holtrich, Christine Solbach, Anton Scharl, Klaus Strebhardt, Thomas Karn, Manfred Kaufmann

Journal:

The Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 270 KB

english, 2001

26

Identification of high risk breast-cancer patients by gene expression profiling

André Ahr, Thomas Karn, Christine Solbach, Tanja Seiter, Klaus Strebhardt, Uwe Holtrich, Manfred Kaufmann

Journal:

Year:

2002

Language:

english

File:

PDF, 213 KB

english, 2002

27

Germ Cell Tumors Overexpress the Candidate Therapeutic target Cyclin B1 Independently of p53 function

De Giorgi, Ugo, Yuan, Juping, Moroni, Mauro, Veronese, Silvio, Sartore-Bianchi, Andrea, Broggini, Massimo, Rosti, Giovanni, Strebhardt, Klaus, Ruffini, Pier Adelchi

Journal:

The International Journal of Biological Markers

Year:

2015

Language:

english

File:

PDF, 379 KB

english, 2015

28

Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 – estrogen has an influence on e-NOS, but not on i-NOS

Sibylle Loibl, Jutta Bratengeier, Vincent Farines, Gunter von Minckwitz, Birgit Spänkuch, Valérie Schini-Kerth, Françoise Nepveu, Klaus Strebhardt, Manfred Kaufmann

Journal:

Pathology - Research and Practice

Year:

2006

Language:

english

File:

PDF, 235 KB

english, 2006

29

Antiproliferative activity of bortezomib alone and in combination with cisplatin or docetaxel in head and neck squamous cell carcinoma cell lines

Jens Wagenblast, Markus Hambek, Mehran Baghi, Wolfgang Gstöttner, Klaus Strebhardt, Hanns Ackermann, Rainald Knecht

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2008

Language:

english

File:

PDF, 460 KB

english, 2008

30

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

Raab, Monika, Lu, Yuning, Kohler, Karsten, Smith, Xin, Strebhardt, Klaus, Rudd, Christopher E.

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.39 MB

english, 2017

31

Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1)

Li, Zhiguo, Lu, Ying, Ahmad, Nihal, Strebhardt, Klaus, Liu, Xiaoqi

Journal:

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

32

Two Additional Protein-Tyrosine Kinases Expressed in Human Lung: Fourth Member of the Fibroblast Growth Factor Receptor Family and an Intracellular Protein-Tyrosine Kinase

Uwe Holtrich, Andreas Brauninger, Klaus Strebhardt and Helga Rubsamen-Waigmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 954 KB

english, 1991

33

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

Raab, Monika, Sanhaji, Mourad, Zhou, Shengtao, Rödel, Franz, El-Balat, Ahmed, Becker, Sven, Strebhardt, Klaus

Journal:

Year:

2019

File:

PDF, 2.20 MB

2019

34

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

Watts, Ellen, Heidenreich, David, Tucker, Elizabeth, Raab, Monika, Strebhardt, Klaus, Chesler, Louis, Knapp, Stefan, Bellenie, Benjamin, Hoelder, Swen

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 4.10 MB

english, 2019

35

PLK (polo-like kinase), a new prognostic marker for oropharyngeal carcinomas

Rainald Knecht, Christine Oberhauser, Klaus Strebhardt

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 28 KB

english, 2000

36

Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ

Nicole Sänger, Katharina E. Effenberger, Sabine Riethdorf, Viviane Van Haasteren, Johannes Gauwerky, Inka Wiegratz, Klaus Strebhardt, Manfred Kaufmann, Klaus Pantel

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 160 KB

english, 2011

37

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

Wolfgang Reindl, Juping Yuan, Andrea Krämer, Klaus Strebhardt, Thorsten Berg

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 715 KB

english, 2008

38

Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

Hock, Björn, Böhme, Beatrix, Karn, Thomas, Feller, Stephan, Rübsamen-Waigmann, Helga, Strebhardt, Klaus

Journal:

Year:

1998

Language:

english

File:

PDF, 627 KB

english, 1998

39

Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression

Steinhauser, Isabel, Langer, Klaus, Strebhardt, Klaus, Spänkuch, Birgit

Journal:

Journal of Drug Targeting

Year:

2009

Language:

english

File:

PDF, 933 KB

english, 2009

40

Drugging Plk1: An attractive approach to inhibit androgen receptor signaling

Strebhardt, Klaus

Journal:

Year:

2015

Language:

english

File:

PDF, 360 KB

english, 2015

41

Polo-Like Kinase 1: Target and Regulator of Transcriptional Control

Martin, Bernd T., Strebhardt, Klaus

Journal:

Year:

2006

Language:

english

File:

PDF, 1.08 MB

english, 2006

42

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

Ilija Androic, Andrea Krämer, Ruilan Yan, Franz Rödel, Regine Gätje, Manfred Kaufmann, Klaus Strebhardt, Juping Yuan

Journal:

Year:

2008

Language:

english

File:

PDF, 926 KB

english, 2008

43

Human papilloma virus load and PD-1/PD-L1, CD8 + and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy

Balermpas, Panagiotis, Martin, Daniel, Wieland, Ulrike, Rave-Fränk, Margret, Strebhardt, Klaus, Rödel, Claus, Fokas, Emmanouil, Rödel, Franz

Journal:

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

44

Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy

Fleischmann, Max, Martin, Daniel, Peña-Llopis, Samuel, Oppermann, Julius, von der Grün, Jens, Diefenhardt, Markus, Chatzikonstantinou, Georgios, Fokas, Emmanouil, Rödel, Claus, Strebhardt, Klaus, Beck

Journal:

Frontiers in Oncology

Year:

2019

Language:

english

File:

PDF, 1.24 MB

english, 2019

45

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

RÃ¶del, Franz, Zhou, Shengtao, GyÅrffy, BalÃ¡sz, Raab, Monika, Sanhaji, Mourad, Mandal, Ranadip, Martin, Daniel, Becker, Sven, Strebhardt, Klaus

Journal:

Frontiers in Oncology

Year:

2020

File:

PDF, 962 KB

2020

46

Cover Picture: A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis (ChemBioChem 7/2009)

Wolfgang Reindl, Juping Yuan, Andrea Krämer, Klaus Strebhardt , Thorsten Berg

Journal:

Year:

2009

Language:

english

File:

PDF, 664 KB

english, 2009

47

Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation

Isabel M. Steinhauser, Klaus Langer, Klaus M. Strebhardt, Birgit Spänkuch

Journal:

Year:

2008

Language:

english

File:

PDF, 329 KB

english, 2008

48

pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner

Mandal, Ranadip, Raab, Monika, Matthess, Yves, Becker, Sven, Knecht, Rainald, Strebhardt, Klaus

Journal:

Molecular Oncology

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

49

Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

Faltus, Timo, Yuan, Juping, Zimmer, Brigitte, Kramer, Andrea, Loibl, Sibylle, Kaufmann, Manfred, Strebhardt, Klaus

Journal:

Year:

2004

Language:

english

File:

PDF, 901 KB

english, 2004

50

A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

Wolfgang Reindl, Juping Yuan, Andrea Krämer, Klaus Strebhardt , Thorsten Berg

Journal:

Year:

2009

Language:

english

File:

PDF, 386 KB

english, 2009

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